I think the best way to quit smoking is not to start, says Dr. Sinclair, who believes people should make an effort to stop smoking because cigarette smoke remains in the body for a long time after you finish your last cigarette and can cause cancer even if it has been years since you lit up. Whilst the shelf life of resveratrol can be extended by avoiding excessive heat. To get metformin, you would need a prescription from your doctor. Dr. David A. Sinclair is a famous author, professor, and scientist of international repute known for his research on aging and its control in the body with natural ingredients, which the scientific community has widely recognized. David doesnt mention this part, but its good practice in yogurt making to avoid unwanted bacteria multiplying later on. Whilst SpermidineLIFE is composed of a standardized wheat germ extract, which itself contains spermidine. The core yogurt making process is combining yogurt bacteria with milk, and keeping the liquid at around 115F for 5-10 hours (often overnight). For those with gluten intolerance, taking it in a pure form may be more ideal, as wheat germ contains small amounts of gluten. After taking the B12/Folate supplement for a few months, in February 2020 David got some blood tests done, and found his B12 levels were double the recommended maximum so he stopped taking it (source: Davids Facebook post). Alpha lipoic acid is found naturally in certain food, and when digested, is used in the cells as a cofactor in mitochondrial energy metabolism25Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling Packer et al. David Sinclair's work with red-wine compound resveratrol was challenged but ultimately proved right. showed that 250mg of NMN daily in 65+year old men raised their NAD levels and improved their muscle strength. 4. Sinclair believes that Fisetin is important in fighting to age. Rhonda Patrick's General Eating Guidelines Rhonda Patrick's Breakfast Breakfast 1 Eggs Tomatillo Salsa Avocado Oil Mustard Powder Kale Grapefruit Breakfast 2 Cereal Blueberries Pomegranate Flaxseed Coconut Milk Raw Cacao Nibs Hydrolized Collagen Powder Almond Butter Yogurt or VSL #3 Rhonda Patrick on Coffee and Intermittent Fasting Helped by lots of green tea, Previously kept meat consumption low and avoided red meat. Im absolutely against cigarettes, says Dr. Sinclair, who urges people to avoid smoking and all other tobacco products because they contain a potent toxin called formaldehyde, which is used in embalming fluid. Im big on intermittent fasting and restricting calories, and I think people should not snack-its much better to have your three meals a day, says Dr. Sinclair, who also advocates skipping breakfast. Fast intermittently. Lunch is the meal he skips most often. Below we will look at various possible buying options. Together with Dr. Rhonda Patrick, he is one of the main proponents of wholesome food eating to delay aging. very . An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol, Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults, Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans, Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance, Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients, Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients, The Effect of Resveratrol Supplementation on CardioMetabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, DoubleBlind Controlled Trial, Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial, Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease, Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A tripleblind, 6month followup, placebocontrolled, randomized trial, One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease, Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue, Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1, Design and synthesis of compounds that extend yeast replicative lifespan, Sirtuin activators mimic caloric restriction and delay ageing in metazoans, Higher spermidine intake is linked to lower mortality: a prospective population-based study, The positive effect of spermidine in older adults suffering from dementia, The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial, Efficacy of Berberine in Patients with Type 2 Diabetes, Metformin and berberine, two versatile drugs in treatment of common metabolic diseases, A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution, Vegetables and Mixed Dishes Are Top Contributors to Phylloquinone Intake in US Adults: Data from the 2011-2012 NHANES, Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease, The relationship between vitamin K and peripheral arterial disease, Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling, Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction, Andrew Huberman Supplements Full List Deep Dive Into What & Why, David Sinclair Supplements List Deep Dive into What & Why (2023), Rhonda Patrick Supplements List Updated February 2023, Andrew Huberman Book Recommendations 25 He Recommends & Why, Andrew Huberman Diet and Routine What He Eats & Why, Rhonda Patrick Fish Oil Brand Choice & Protocol 2023 Update, $2.48/gram ($62 / 25g) - when using 10% off, $1.84/gram ($184/ 100g) - when buying 4 tubs, $1.86/gram ($85 / 45g) - when using 10% off, $2.70/gram ($324 / 120g) - when buying 4 bottles, Statin a cholesterol lowering prescription drug taken since his early 20s due to family history of cardiovascular disease, Coffee in the morning (once per day), then green tea after that, Intermittent fasting aims to skip at least 1 meal per day. David opts to take 800mg of Metformin at night (see this section of episode #4 of his podcast), except on nights when he plans exercise the next day. Characterized by eating more healthy foods like vegetables, fruits, nuts, whole grains, healthy fats, and omega-3 fatty acids, and less unhealthy foods like red and processed meats, sugar . Berberine is interesting to many people because it has similar properties to metformin, but it doesnt require a doctors prescription. This emulates the method David uses to take his NMN; in capsules swallowed with a glass of water. You can search the ~290 comments using the search box at the top of the comments. He also said that he - and his 81-year-old father - eat one major meal a day. The goal of this blog is to share information around health and longevity, with the hope that others find it useful. For foods rich in these, see table 1 in this research paper. They measured strength via a 30-second chair stand test, walking speed, and grip strength measurements. But he argues that if he does . Time-restricted feeding, which involves not eating for at least 16 hours within 24 hours, is Dr. Sinclair's preferred fasting method. In his podcast interview with Dave Asprey (link), David mentions taking alpha lipoic acid. David mentions this at 1:17:54 of his Ben Greenfield interview, noting that 50% purity can even give diarrhea, because theres other stuff that comes along with the molecule. Unfortunately, many people are low in vitamin K1, and therefore may have inadequate levels of K1 to support adequate calcium transport. Theres an evolutionary theory that the reason we like the heat is that it simulates our African origins, where everything was hot and tropical, says Dr. Sinclair. You might have heard about Dr. David Sinclair on the Joe Rogan Experienceand you are now curious about what does he eat and what supplements he does take. Quercetin has many antioxidant and anti-inflammatory properties but recently, David Sinclair has stated that he takes it daily as a senolytic. However, because this was a study based upon diets, evaluated through questionnaires, its possible that other factors were responsible for the health benefits. David has his own supply in his lab that he takes, but fortunately you can pick up NMN and Resveratrol on the Renue By Science website. Roughly 84 million . Mark Mattson, a professor of Neuroscience at John Hopkins University, gave a speech at TEDxJohnHopkinsUniversity talking about the extensive benefits of fasting for your brain and body. Dr David Sinclair | Sweet Fruit " Darius Behi says: March 29, 2021 at 10:03 pm. Noting that: Due to the poor aqueous solubility exhibited by resveratrol, digestive absorption is greatly influenced by drug dissolution rate. For example, a longevity pathway called nTor is sensitive to the number of amino acids that come into the body. Vitamin D is an essential micronutrient, and is thought to exercise significant effect on at least 200 of our genes21A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution Ramagopalan et al. Dr. Sinclair emphasizes that you cant take shortcuts when it comes to planning a diet and exercise regimen-the best way to prolong life expectancy is to eat st healthy balanced diet food, taking care not to overload your body with fructose or simple sugars. 1 gram of nmn with water or under tongue in the morning. Both have senolytic and SIRT1 activating properties. The sooner you quit smoking, the better off you are if you quit at age 20; your life expectancy is almost normal., Dr. Sinclair believes people should make an effort to eat fruits and vegetables every day, either in a smoothie or salad. This has a host of knock-on effects (visualized below), some of which are involved in beneficial processes like mediating inflammation and increasing autophagy (cellular cleanup). The compound could have all the benefits of caloric restriction without the starvation. David mentions in his interview with Rhonda Patrick a few nuances around the storage of resveratrol: David takes his resveratrol in the morning, mixed into a spoon of homemade yogurt (using the Bravo starter culture), in order to increase its bio-availability. Your doctor test, walking speed, and grip strength measurements pathway nTor. It has similar properties to metformin, you would need a prescription from doctor! The hope that others find it useful a glass of water buying options strength via a chair... Life of resveratrol can be extended by avoiding excessive heat inadequate levels of K1 to support calcium! Fisetin is important in fighting to age Sinclair has stated that he - his! 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